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<div style="text-align: center;"><big><big><span style="font-weight: bold;">The World Integrative Research
Initiative</span></big></big><br>
</div>
<br>
The undersigned organisations agree that a paradigm shift is necessary
in the way in which biomedical research is carried out. It is necessary
that laboratory and clinical observations are accumulated and made
accessible to all those who can use them to develop or to validate new
hypotheses; it is necessary that the knowledge we have on a sub-system,
a certain dimensional scale, or a certain biophysical aspect can be
formalised and interconnected to others that are being developed on
contiguous sub-systems, scales, domains. We call this new approach
Integrative Biomedical Research.<br>
<br>
The undersigned organisations agree to foster by all means an
international collaboration aimed to promote the development of
Integrative Research in biomedicine by pursuing collectively or
independently the following common goals:<br>
<ul>
  <li><i>Common Objectives</i></li>
  <ul>
    <li>Call the same things by the same name: consensus on
definitions</li>
    <li>Define and constantly revise the goals of the Integrative
Research Initiative</li>
    <li>Develop descriptions of the expected results, and of
their impact on the life of humanity</li>
  </ul>
  <li><i>Research Challenges</i></li>
  <ul>
    <li>Promote consensus over the grand challenges Integrative
Research poses</li>
    <li>Suggest research and technological development objectives
considered essential for success of the Integrative Research Initiative</li>
  </ul>
  <li><i>Resources Required</i></li>
  <ul>
    <li>Maintain an Integrative Research Investment Monitor which
lists all Integrative Research projects and the relevant resources
invested on them</li>
    <li>Develop a lobbying strategy that allow the World
Integrative Research Initiative to support integrative research within
public and private grant agencies</li>
    <li>Start a collective open source software project for
supporting this integrative research initiative</li>
    <li>Promote studies on long-term sustainability and related
business models</li>
  </ul>
  <li><i>Ethical, Legal and Gender Issues</i></li>
  <ul>
    <li>Maintain the GEL (Gender-Legal-Ethical) observatory to
monitor the legal barriers to the development of Integrative Research </li>
  </ul>
  <li><i>Interoperability</i></li>
  <ul>
    <li>Develop standards that ensure the federation of digital
libraries and repositories relevant to the Integrative Research
Initiative</li>
    <li>Create a central repository of Software Tools that list
and comment all software that might be useful for an Integrative
Research project</li>
    <li>Develop, maintain and harmonise semantic representations
of the Integrative Research knowledge space</li>
  </ul>
  <li><i>Community Building</i></li>
  <ul>
    <li>Creating a single web site or a federated portal that can
provide a single entry point for the whole Integrative Research
community</li>
    <li>Promote Integrative Research with a top-down approach by
ensuring that each major scientific society has an Integrative Research
panel (this includes IEEE, IUPS, ASME, IFMBS, EMABES, etc.)</li>
    <li>Promote Integrative Research with a bottom-up approach by
encouraging initiatives aimed at fostering the creation of new
Integrative Research projects, and the idea of team science in
biomedical research</li>
    <li>Publish Integrative Research News, a monthly electronic
newsletter</li>
    <li>Promote initiatives that establish a sense of community,
such as logos, T-shirts, etc.</li>
  </ul>
  <ul>
    <li>Run the World Integrative Research Conference and other
similar events, e.g. a small but highly publicised event to which only
those who have most actively developed the field in the past year are
invited.</li>
  </ul>
</ul>
<br>
<table style="width: 80%; text-align: left; margin-left: auto; margin-right: auto;" border="1" cellpadding="2" cellspacing="2">
  <tbody>
    <tr>
      <td style="font-weight: bold;">Consortium</td>
      <td style="font-weight: bold;">Country</td>
      <td style="font-weight: bold;">Representative</td>
      <td style="font-weight: bold;">Agreed on</td>
    </tr>
    <tr>
      <td><a href="http://www.europhysiome.org">Europhysiome</a></td>
      <td>Europe</td>
      <td>Gordon Clapworthy</td>
      <td>13 March 2007</td>
    </tr>
    <tr>
      <td><a href="http://www.physiome.org.nz/">IUPS
Physiome</a></td>
      <td>New Zeland</td>
      <td>Peter Hunter</td>
      <td>14 March 2007</td>
    </tr>
    <tr>
      <td><a href="http://www.physiome.org/">NSR
Physiome</a></td>
      <td>USA</td>
      <td>James
B. Bassingthwaighte&nbsp;</td>
      <td>15 March 2007</td>
    </tr>
    <tr>
      <td><a href="http://simbios.stanford.edu/">SIMBIOS</a></td>
      <td>USA</td>
      <td>Scott Delp</td>
      <td>16 March 2007</td>
    </tr>
    <tr>
      <td><a href="http://www.livinghuman.org/">LHDL</a></td>
      <td>Europe</td>
      <td>Marco Viceconti</td>
      <td>8 May 2007<br></td>
    </tr>
    <tr>
      <td><a href="http://www.aneurist.org/">@neurIST</a></td>
      <td>Europe</td>
      <td>Alejandro Frangi</td>
      <td>9 april 2007<br>
      </td>
    </tr>
    <tr>
      <td><a href="http://www.biomedtown.org/biomed_town/VPH/VPHEvents/shanghai">VMHC</a></td>
      <td>China</td>
      <td>Wang Chengtao&nbsp;&nbsp;</td>
      <td>16 March 2007</td>
    </tr>
    <tr>
      <td>Japanese Physiome Initiative</td>
      <td>Japan</td>
      <td>Yoshihisa
Kurachi&nbsp;</td>
      <td>in progress<br></td>
    </tr>
  </tbody>
</table>
&nbsp;<br>
If your research consortium also want subscribe this agreement please write an email <a href="mailto:webmaster@biomedtown.org">to us</a>.<br>
<br>


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