The 2nd MEI International Symposium organised by the Global Centre of Excellence (gCOE) program on in silico medicine, held in Osaka, Japan, on 7-9 December 2007, saw the participation of some of the key figures in Integrative Research worldwide, both from academia and from funding agencies.

The EuroPhysiome community was represented by Denis Noble (University of Oxford), Rod Smallwood (University of Sheffield) and Marco Viceconti (Rizzoli Institute). Peter Hunter (University of Auckland), Andrew McCulloch (UCSD), and the conference organiser, Yoshi Kurachi (University of Osaka), represented the IUPS Physiome Project. We also had representatives of the funding agencies: the European Commission represented by Ilias Iakovidis and United States NIH, represented by Grace Peng, who also represented the Interagency Modeling and Analysis Group (IMAG) and the Multiscale Modeling Consortium supported by the IMAG Multi-Scale Modeling Initiative (MSM). The Japanese Ministry of Science and Technology was represented by Yutaka Hishiyama, that is supporting the leading project Biosimulation, and the creation of the Global Centre of Excellence in In silico medicine.

The presence of these key figures transformed the event also in a very good opportunity to strengthen the scenarios of international co-operation on Biomedical Integrative Research. After two days of intense work the "Osaka Accord: was signed among all participants.

While the Accord in itself is little more than a declaration of good will, it capture a common interest in the international pursue of the objectives set by Integrative Research, translated in concrete goals such as those listed in the WIRI Agreement, that is cited as an example of a concrete agenda to be followed. Moreover, based on the Osaka Accord, the participating funding agencies started closer talks on possible global co-operation between their relevant programs.