The paper advocates that it is necessary to create a federation of clinical databases that can link the genotypes to the drug-response phenotypes. In my opinion we can claim that this is part of the Physiome Project.

Source: Nature Reviews Drug Discovery 5, 23-26 (February 2006)

Title: A call for the creation of personalized medicine databases

Authors: David Gurwitz, Jeantine E. Lunshof and Russ B. Altman.

Abstract: The success of the Human Genome Project raised expectations that the knowledge gained would lead to improved insight into human health and disease, identification of new drug targets and, eventually, a breakthrough in healthcare management. However, the realization of these expectations has been hampered by the lack of essential data on genotype–drug-response phenotype associations. We therefore propose a follow-up to the Human Genome Project: forming global consortia devoted to archiving and analysing group and individual patient data on associations between genotypes and drug-response phenotypes. Here, we discuss the rationale for such personalized medicine databases, and the key practical and ethical issues that need to be addressed in their establishment.