The Big Island of Hawaii, 4th-8th January, 2008. The thirthteenth Pacific Symposium on Biocomputing (PSB) will bring together top researchers from around the world, who are involved in biological problems at different levels, so to foster the interactive enviroment and initiate multi-scale collaborations and activities. The development of simulation systems which may operate at multiscale level is required to better understand human physiology and to allow for predictive capabilities of disease prevention and treatment.

Submission topics (not limited to) => Physics-based modeling and simulations at all scales:

• Multiscale: moethods for making the connection between continuum macroscale models (e.g. fluid) and discrete molecular phenomena (e.g. molecular behaviour); model reduction and systems identification for multiscale dynamical systems; algorithmic tools for multi-scale modeling systems using optimization and simulation in time and space; mesoscale simulation of biomechanical networks; finite-element method for molecules, cells, tissues and organs; functional coupling within a scale;
• Molecular: protein dynamics and conformational changes; coarse-grained model for biomolecules; molecular biology of ion channels and transporters; protein-protein interaction networks; molecular mechanics of disease;
• Cellular: excitation-contraction coupling and mechanoelectric feedback in normal and diseased cells; metabolic and neurohumoral regulation of excitation-contraction coupling; cellular force transmission; motility and cytoskeletal dynamics;
• Tissue, organ, organisms: tissue mechanics; cardiovascular systems modeling; dynamic simulation of neuromuscular systems; patient-specific modeling; cardiac resynchronization therapy.

The paper must be submitted due to by 16th July, 2007.

Paper guidelines